Beneficial Effects of Cynaroside on Cisplatin-Induced Kidney InjuryIn VitroandIn Vivo
نویسندگان
چکیده
منابع مشابه
Evaluation of the effects of taurine on cisplatin-induced kidney injury and oxidative stress in male rats
Introduction: Cisplatin is used as a chemotherapeutic agent for the treatment of human ovarian and testicular cancers. This study was designed to investigate the protective role of taurine against cisplatin-induced kidney injury. Methods: Male Wistar rats were divided into 4 groups (n=8) (1) saline-treated group (2) cisplatin-treated group (10 mg/kg, i.p.), (3) group that received taurine (2...
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This study investigated the protective effect of fish oil (FO) on cisplatin (CP) toxicity in the rat liver. Twenty-eight rats were divided equally into four groups, with the first being a control group. The second group (CP group) was given 7 mg/kg of CP and the third group (FO group) was given 1 FO softgel/rat/day for 14 days. The rats in the fourth group (CP + FO group) were treated with both...
متن کاملThe beneficial effects of fish oil following cisplatin-induced oxidative and histological damage in liver of rats
This study investigated the protective effect of fish oil (FO) on cisplatin (CP) toxicity in the rat liver. Twenty-eight rats were divided equally into four groups, with the first being a control group. The second group (CP group) was given 7 mg/kg of CP and the third group (FO group) was given 1 FO softgel/rat/day for 14 days. The rats in the fourth group (CP + FO group) were treated with both...
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Background and objectives: Cisplatin (CP), as an anticancer drug, causes nephrotoxicity. Zataria multiflora Boiss. (ZM), a plant which has been used as a herbal medicine for a variety of ailments. Our study aimed to examine the effects of ZM on cisplatin induced nephrotoxicity. Methods: Thirty-two male mice were randomly divided into four groups. The co...
متن کاملLipocalin2 Protects Human Embryonic Kidney Cells against Cisplatin–Induced Genotoxicity
Cisplatin is one of the most useful chemotherapeutics which performs its cytotoxic effectvia accumulation of platinum resulting in oxidative stress, and destruction of cell DNA. Thiscould probably cause secondary cancers in healthy tissues. Lipocalin2 (Lcn2) is a protein whichits expression is increased in oxidative stresses. Therefore, the present study was performedto evaluate the protective ...
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ژورنال
عنوان ژورنال: Toxicological Research
سال: 2018
ISSN: 1976-8257,2234-2753
DOI: 10.5487/tr.2018.34.2.133